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Prothionamide

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    Prothionamide
  • Prothionamide
Cat No: 16074
Biochemicals - Anti-Infection
Cayman

Prothionamide is a bactericidal thioamide effective against M. tuberculosis (MIC = ~0.5 µg/ml), M. leprae (MIC = 0.8-1.6 mg/L), and M. avium.{26434} It forms a covalent adduct with nicotinamide adenine dinucleotide that inhibits mycobacterial InhA, th...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 2-propyl-4-pyridinecarbothioamide
Correlated keywords:
  • thioamides drugs leprosy tuberculosis inhibitors antibacterial bactericidal M. tuberculosis mycobacterium M. leprae M. avium covalent adducts nicotinamides adenine dinucleotide inhibits inhibition mycobacteria mycobacterial InhA enoyl-acyl ACP reductase mycolic acids biosynthesis ektebin 9778 R.P. protionamid protionamide protionizina protion RP 9778 RP9778 RP-9778 TH 1321 TH1321 TH-1321 trevintix tuberex anti-bacterial anti bacterial
Product Overview:
Prothionamide is a bactericidal thioamide effective against M. tuberculosis (MIC = ~0.5 µg/ml), M. leprae (MIC = 0.8-1.6 mg/L), and M. avium.{26434} It forms a covalent adduct with nicotinamide adenine dinucleotide that inhibits mycobacterial InhA, the enoyl-acyl ACP reductase involved in mycolic acid biosynthesis, with a Ki value of 2 nM.{26434}
Size 500 mg
Shipping dry ice
CAS Number 14222-60-7
Molecular Formula C9H12N2S
SMILES NC(C1=CC=NC(CCC)=C1)=S
Molecular Weight 180,3
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.39
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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