CD2665

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CD2665

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Cat No: 16031

Biochemicals - Receptor Pharmacology

CD2665 is a selective retinoic acid receptor (RAR)β and RARγ antagonist (Kds = 110, 306, and > 2,250 nM for RARγ, RARβ, and RARα, respectively, with no binding at RXRα).{18516} At 10-7 M, it has been used to abrogate retinoic acid (Item No. 11017)-ind...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[6-[(2-methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl]-benzoic acid

Correlated keywords:

retinoic acid retinoid signaling RAR? RAR? RAR ? ? RARg RARbCD-2665 antagonist receptor

Product Overview:
CD2665 is a selective retinoic acid receptor (RAR)β and RARγ antagonist (Kds = 110, 306, and > 2,250 nM for RARγ, RARβ, and RARα, respectively, with no binding at RXRα).{18516} At 10-7 M, it has been used to abrogate retinoic acid (Item No. 11017)-induced antiproliferative and antidifferentiative effects on sebocyte growth.{18516} This compound has been used in animal and in vitro cell models to explore the role of retinoid signaling in a number of biological processes including memory formation and tumor proliferation.{30066,30067}

Size	1 mg
Shipping	dry ice
CAS Number	170355-78-9
Molecular Formula	C₃₁H₃₄O₅
SMILES	OC(C1=CC=C(C2=CC(C=C(C34C[C@H]5C[C@H](C[C@@H](C4)C5)C3)C(OCOCCOC)=C6)=C6C=C2)C=C1)=O
Molecular Weight	486,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2918.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.