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Zalcitabine

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    Zalcitabine
  • Zalcitabine
Cat No: 16019
Cayman

Zalcitabine is an analog of pyrimidine derived from deoxycytidine with the replacement of the hydroxyl group in position 3’ with a hydrogen.{8362} In cells, it is phosphorylated to the active triphosphate form, ddCTP, which acts as a substrate for HIV...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 2',3'-dideoxy-cytidine
Correlated keywords:
  • 176485-?55-?5 anti-retroviral anti retroviral antiretroviral HIV reverses transcriptases AIDS nucleosides viral replications inhibitors inhibits inhibitions analogs pyrimidines substrates NSCs 606170 NSC606170 NSC-606170 Ros 24-2027/000 Ro24-2027/000 Ro-24-2027/000 dideoxycytidines ddCTP DNA infectious diseases nucleotides hivid d 2c
Product Overview:
Zalcitabine is an analog of pyrimidine derived from deoxycytidine with the replacement of the hydroxyl group in position 3’ with a hydrogen.{8362} In cells, it is phosphorylated to the active triphosphate form, ddCTP, which acts as a substrate for HIV reverse transcriptase (Ki = 51 nM).{26225,26224} It incorporates into viral DNA where it terminates chain elongation when the missing hydroxyl group is encountered. Zalcitabine was the third antiretroviral approved by the FDA for treatment of HIV infection and AIDS.{24196}
Size 25 mg
Shipping dry ice
CAS Number 7481-89-2
Molecular Formula C9H13N3O3
SMILES OC[C@@H]1CC[C@H](N2C=CC(N)=NC2=O)O1
Molecular Weight 211,2
Formulation A crystalline solid
Purity ≥95%
Custom Code 2933.49
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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