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Zoniporide (hydrochloride)

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    Zoniporide (hydro<wbr>chloride)
  • Zoniporide (hydro<wbr>chloride)
Cat No: 16004
Biochemicals - Transporter & Exchanger Modulators
Cayman

The sodium-hydrogen exchanger isoform-1 (NHE-1) is the most predominant isoform of the Na+/H+ exchanger and is expressed in the heart where it contributes to cardiomyocyte pH homeostasis.{22706} It plays an important role in the myocardial response to ...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • N-(aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide, monohydrochloride
Correlated keywords:
  • 241800-98-6 sodium-hydrogen sodiums hydrogens isoforms 1 one exchangers isoform-1 NHE-1 Na+/H+ NHE cardioprotection selective inhibits inhibitions inhibitors NHE1 reduces reductions reducing infarct sizes rabbits myocardial ischemia reperfusion hemodynamics cardiac functions CPs 597396 CP-597396 CP597396 ions channels pumps blockers cardiology sodium/hydrogen ischemia-reperfusion hearts HCl
Product Overview:
The sodium-hydrogen exchanger isoform-1 (NHE-1) is the most predominant isoform of the Na+/H+ exchanger and is expressed in the heart where it contributes to cardiomyocyte pH homeostasis.{22706} It plays an important role in the myocardial response to ischemia-reperfusion. Zoniporide inhibits human NHE-1 with an IC50 value of 14 nM, displaying greater than 150-fold selectivity over other NHE isoforms.{25880} It has been shown to reduce infarct size in a rabbit myocardial ischemia-reperfusion model without adversely affecting hemodynamics or cardiac function.{22706} In isolated heart, zoniporide reduced infarct size with an EC50 value of 0.25 nM.{25880}
Size 1 mg
Shipping dry ice
CAS Number 241800-97-5
Molecular Formula C17H16N6O • HCl
SMILES O=C(C(C=N1)=C(C2CC2)N1C3=C4C(N=CC=C4)=CC=C3)/N=C(N)/N.Cl
Molecular Weight 356,8
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.49
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

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