Losartan Carboxylic Acid

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Cat No: 15957

Biochemicals - Receptor Pharmacology

Losartan carboxylic acid is a physiologically active metabolite of losartan (Item No. 10006594), produced by cytochrome P450 isoforms in the liver.{28030} Like the parent compound, losartan carboxylic acid is a potent AT1 antagonist (Kis = 0.57 and 0....

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid

Correlated keywords:

biochemical receptor antagonist endocrinology receptor biochemistry hypertension vascular disease active metabolite EXP3174 143412-42-4 913611-26-4 1345339-56-1 913611-27-5 physiologically active metabolite cytochrome P450 isoform liver potent AT1 depressor response vasodilation

Product Overview:
Losartan carboxylic acid is a physiologically active metabolite of losartan (Item No. 10006594), produced by cytochrome P450 isoforms in the liver.{28030} Like the parent compound, losartan carboxylic acid is a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation.{28032,28031,21001} When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan.{21001} However, the metabolite has very low oral bioavailability.{21001} Losartan, but not its metabolite, inhibits platelet aggregation in vitro.{20999}

Size	1 mg
Shipping	dry ice
CAS Number	124750-92-1
Molecular Formula	C₂₂H₂₁ClN₆O₂
SMILES	[H]N1N=NN=C1C2=CC=CC=C2C3=CC=C(CN4C(C(O)=O)=C(Cl)N=C4CCCC)C=C3
Molecular Weight	436,9
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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