CV-6209 (chloride)

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CV-6209 (chloride)

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Cat No: 15955

Biochemicals - Receptor Pharmacology

CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor, inhibiting aggregation of rabbit and human platelets induced by PAF with IC50 values of 75 and 170 nM, respectively.{27971} It has little action on platelet aggregation i...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-(2-acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl-pyridinium, monochloride

Correlated keywords:

760912-44-5 117064-?08-?1 116953-66-3 131729-40-3 116953-65-2 biochemicals receptors antagonists platelet-activating factors signals transduction hypertension vascular diseases inflammation atherosclerosis oxidative injury signaling CV6209 CV 6209 platelets PAF inhibits inhibitors inhibitions aggregation rabbits humans arachidonic acid ADP collagen histamine bradykinin isoproterenol

Product Overview:
CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor, inhibiting aggregation of rabbit and human platelets induced by PAF with IC50 values of 75 and 170 nM, respectively.{27971} It has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen.{27971} CV-6209 is bioavailable, as it prevents PAF-induced hypotension in rats, while not blocking hypotension triggered by arachidonic acid (Item No. 90010), histamine, bradykinin (Item No. 15539), or isoproterenol (Item No. 15592).{27971} CV-6209 is used to study the role of PAF receptor signaling in vitro and in vivo.{27973,27972}

Size	500 µg
Shipping	dry ice
CAS Number	100488-87-7
Molecular Formula	C₃₄H₆₀N₃O₆ • Cl
SMILES	O=C(C)N(C(OCC(OC)COC(NCCCCCCCCCCCCCCCCCC)=O)=O)CC1=CC=CC=[N+]1CC.[Cl-]
Molecular Weight	642,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.39
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.