17-trifluoromethylphenyl-13,14-d

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17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F_1?

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Cat No: 15895

Biochemicals - Lipids

A number of 17-aryl trinor and 16-aryloxy tetranor prostaglandin F2α derivatives have been approved for the treatment of glaucoma.{8941,9341,8839} These “ring” prostaglandin (PG) analogs have improved efficacy over the PGs with an n-alkyl lower side ch...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

9?,11?,15S-trihydroxy-17-trifluoromethylphenyl-18,19,20-trinor-prostan-1-oic acid

Correlated keywords:

PGF1alpha PGF1.alpha. analogs FP prostaglandins eyes ophthalmology ophthalmological intraocular glaucoma esters receptors agonists IOP pressure

Product Overview:
A number of 17-aryl trinor and 16-aryloxy tetranor prostaglandin F2α derivatives have been approved for the treatment of glaucoma.{8941,9341,8839} These “ring” prostaglandin (PG) analogs have improved efficacy over the PGs with an n-alkyl lower side chain. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.{9736} 17-trifluoromethylphenyl-13,14-dihydro trinor PGF1α (17-TFM-PGF1α) is a typical “ring” analog reminiscent of the trifluoromethyl-phenoxy ring of Travoprost. The a chain of 17-TFM-PGF1α is saturated, making this compound a formal member of the one-series PGs. Recent work has shown that in the “ring” series of analogs, this modification has little impact on FP receptor binding.{9668} As an ocular hypotensive agent, it is expected that 17-TFM-PGF1α would act very much like the free acid of latanoprost.

Size	1 mg
Shipping	dry ice
CAS Number	1027401-98-4
Molecular Formula	C₂₄H₃₅F₃O₅
SMILES	O[C@@H]1[C@H](CCCCCCC(O)=O)[C@@H](CC[C@@H](O)CCC2=CC(C(F)(F)F)=CC=C2)[C@H](O)C1
Molecular Weight	460,5
Formulation	A solution in methyl acetate
Purity	≥98%
Custom Code	2937.50
UNSPSC code	12352100

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17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1?