Amitriptyline (hydrochloride)

Confirm delete?

Zoom

Cat No: 15881

Biochemicals - Receptor Pharmacology

Amitriptyline is a first generation tricyclic antidepressant.{25873} It inhibits serotonin (5-HT) uptake by isolated human platelets by 39 and 68% when used at concentrations of 1 and 4 µg/ml, respectively, and inhibits norepinephrine uptake in rat br...

This product can only be bought through Cayman Chemical. Please contact us.

Product Overview
Data
Downloads
About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine, monohydrochloride

Correlated keywords:

50-48-6 8058-?15-?9 neurosciences inhibitors receptors antagonists signals transduction tricyclic antidepressants serotonin norepinephrine transporters inhibits inhibitions 5-HT2A antagonizes histamine H1 muscarinic acetylcholine ?1- adrenergic alpha1- adrenergic .alpha.1- adrenergic a1- adrenergic HCl adepril amicen amil 25 amilent amilit amineurin amiplin amiprin amitid amitril amitrip chlorides amyline amyzol anapsique apo-amitriptyline damilen deprex elatrol elatrolet enafon etravil euplit lantron laroxyl larozyl lentizol miketorin NIH 10794 NIH10794 NIH-10794 noriline novoprotect pinsanu pinsaun redomex Ro 4-1575 saroten retard sarotena sarotex sylvemid syneudon teperin trepiline tridep tripta triptizol trynol tryptal tryptanol tryptine tryptizol trytomer uxen vanatrip Domical Elavil Endep Saroten

Product Overview:
Amitriptyline is a first generation tricyclic antidepressant.{25873} It inhibits serotonin (5-HT) uptake by isolated human platelets by 39 and 68% when used at concentrations of 1 and 4 µg/ml, respectively, and inhibits norepinephrine uptake in rat brain by 77% when administered at a dose of 10 mg/kg.{61584,61585} It is also an antagonist of the 5-HT receptor subtype 5-HT2A (Ki = 20 nM), as well as histamine H1, muscarinic acetylcholine, and α1-adrenergic receptors (Kis = 1.1, 18, and 27 nM, respectively).{25919,25914,25803} Amitriptyline (5-25 µM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide (Item No. 10681) or recombinant human acid sphingomyelinase.{54655} Formulations containing amitriptyline have been used in the treatment of depression and nerve pain. This product is also available as an analytical reference standard (Item Nos. 19029
19031).

Size	5 g
Shipping	dry ice
CAS Number	549-18-8
Molecular Formula	C₂₀H₂₃N • HCl
SMILES	CN(C)CC/C=C1C2=C(C=CC=C2)CCC3=C/1C=CC=C3.Cl
Molecular Weight	313,9
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2921.59
UNSPSC code	12352100

Technical File

MSDS

Click here to ask for your quote and get 15% off Cayman's products.

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.