STAT5 Inhibitor

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STAT5 Inhibitor

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Cat No: 15784

Biochemicals - Small Molecule Inhibitors

Signal Transducers and Activators of Transcriptions (STATs) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokine...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazide 3-pyridinecarboxylic acid

Correlated keywords:

1187749-60-5 1082723-82-7 signals transducers and activators of transcriptions STATs transcription factors inhibitors inhibits inhibitions cancers SH2 SH 2 two domains STA5b STAT5? STA 5b STA-5b STAT-5b STAT 5b STAT 5 b STAT 5? STAT-5? STAT 5 ? beta STAT-5 STAT STAT 5 five STAT5? STAT5 ? STAT-5? STAT 5 ? alpha genes regulations regulates regulators intracellular signaling prevents activations cytoplasmic latent expressions polypeptides EPO peptides cytokines interferons growth isoforms leukemias tumors , nonpetidic nicotinoyl hydrazones suppresses blocks cells permeable DNA binding binds K562 nuclear extracts STAT3 STAT 3 STAT-3 STAT1 STAT 1 STAT-1

Product Overview:
Signal Transducers and Activators of Transcriptions (STATs) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors.{19346,19347,5047} STAT5, which consists of two isoforms STAT5α and STAT5β, is known to be overactive in several kinds of leukemias and various solid tumors. STAT5 Inhibitor is a cell-permeable, nonpetidic nicotinoyl hydrazone that suppresses STAT5 by targeting its SH2 domain (IC50 = 47 µM against STAT5β SH2 domain EPO peptide binding activity).{25879} Comparatively, this compound exhibits reduced potency towards inhibiting the SH2 domain of STAT1, STAT3, or Lck (IC50 > 500 µM).{25879} STAT5 Inhibitor has been shown to block STAT5/STAT5 DNA binding in K562 nuclear extracts.{25879}

Size	5 mg
Shipping	dry ice
CAS Number	285986-31-4
Molecular Formula	C₁₆H₁₁N₃O₃
SMILES	O=C(N/N=C/C1=COC(C=CC=C2)=C2C1=O)C3=CC=CN=C3
Molecular Weight	293,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2918.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.