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Loratadine

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    Loratadine
  • Loratadine
Cat No: 15625
Biochemicals - Receptor Pharmacology
Cayman

Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM).{25629,22788,25628} It has been shown to inhibit the release of leukotriene C4 (IC50 = 8 µM) and histamine (IC50 = 11...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid, ethyl ester
Correlated keywords:
  • antiallergy anti allergy anti-allergy allergies allergic bronchospasm histamines H1 receptors antagonist nonsedating antihistamine anti-histamine inverse agonists LTC4 histamine leukotrienes LTCs LTs LTC4 peripheral inverse agonist non-sedating nonsedating mast cells bronchospasm alavert anhissen bonalerg civeran claratyne claritine clarity clarityne clarotadin cronopen erolin flonidan fristamin histaloran klarifer klaritin lertamine lisino lomilan loracert loradex loranox lorastine loratadine loratidine loratyne lorfast lowadina optimin polaratyne pylor restamine Sch 29851 sch29851 sch-29851 sensibit sohotin tadine velodan zeos Claritin
Product Overview:
Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM).{25629,22788,25628} It has been shown to inhibit the release of leukotriene C4 (IC50 = 8 µM) and histamine (IC50 = 11 µM) from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs with an ED50 value of 0.40 mg/kg.{25627} Formulations containing loratadine have been used in the treatment of allergic rhinitis and chronic idiopathic urticaria.
Size 5 mg
Shipping dry ice
CAS Number 79794-75-5
Molecular Formula C22H23ClN2O2
SMILES ClC(C=C1)=CC(CCC2=C/3N=CC=C2)=C1C3=C4CCN(C(OCC)=O)CC/4
Molecular Weight 382,9
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.39
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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