ICI 118551 (hydrochloride)

Biochemicals - Receptor Pharmacology

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Cat No: 15591

Biochemicals - Receptor Pharmacology

ICI 118551 is a potent, selective antagonist of the β2-adrenergic receptor (Ki = 0.7 nM for the β2 receptor, compared with 49.5 and 611 nM for β1 and β3 receptors, respectively).{25395,25151} It is active in vivo and is often used to evaluate the acti...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2R,3R)-rel-1-[(2,3-dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol, monohydrochloride

Correlated keywords:

receptors antagonists neurosciences vascular diseases cardiology 72795-26-7 123620-72-4 ICI 118551 ICI118,551 ICI-118,551 ICI118551 ICI-118551 ?2-adrenergic ?1 ?2 ?3 in vivo adrenergic agonists ICI 111581 ICI111581 ICI-111581 ICI 111,581 ICI111,581 ICI-111,581 HCl

Product Overview:
ICI 118551 is a potent, selective antagonist of the β2-adrenergic receptor (Ki = 0.7 nM for the β2 receptor, compared with 49.5 and 611 nM for β1 and β3 receptors, respectively).{25395,25151} It is active in vivo and is often used to evaluate the actions of adrenergic receptor agonists.{25421,23875,25153}

Size	10 mg
Shipping	room temp.
CAS Number	72795-01-8
Molecular Formula	C₁₇H₂₇NO₂ • HCl
SMILES	CC1=C(CCC2)C2=C(OC[C@H](O)[C@@H](C)NC(C)C)C=C1.Cl
Molecular Weight	313,9
Formulation	A crystalline solid
Purity	≥99%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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