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Mdivi 1

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    Mdivi 1
  • Mdivi 1
Cat No: 15559
Biochemicals - Small Molecule Inhibitors
Cayman

Mitochondrial fusion and division proteins function via self assembly to regulate membrane dynamics during various cellular events. For example, the self assembly of dynamin-1, a mitochondrial protein that facilitates endocytosis, with a dynamin relate...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 3-(2,4-dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
Correlated keywords:
  • mitochondria mitochondrial fusion divisions proteins self assembly apoptosis GTP hydrolysis dynamin-1 endocytosis dynamin related-GTPase DRP Dnm1 inhibitors quinazolinone membranes permeabilization Bid Bax Bak cytochromes c cells death inhibits inhibition yeast mammals Mdivi1 Mdivi-1 blocks blocking in vivo vitro cancers hearts failure ischemia reperfusion injuries
Product Overview:
Mitochondrial fusion and division proteins function via self assembly to regulate membrane dynamics during various cellular events. For example, the self assembly of dynamin-1, a mitochondrial protein that facilitates endocytosis, with a dynamin related-GTPase (Dnm1 (yeast)/Drp1(mammals)), a mitochondrial protein that functions during mitochondrial division, is thought to regulate apoptosis.{25445} Mdivi 1 is a quinazolinone derivative that selectively inhibits mitochondrial division by blocking dynamin GTPase activity in yeast (IC50 = 1-10 μM) and mammalian cells (IC50 = ~50 μM).{25445} It has been shown to prevent apoptosis by inhibiting mitochondrial outer membrane permeabilization in vivo and to block Bid-activated Bax/Bak-dependent cytochrome c release from mitochondria in vitro.{25445} It has been used to maintain mitochondrial integrity and to prevent cell death in models of pathological conditions including cancer, heart failure, and ischemia and reperfusion injuries.{25446}
Size 5 mg
Shipping dry ice
CAS Number 338967-87-6
Molecular Formula C15H10Cl2N2O2S
SMILES SC(N1C2=C(Cl)C=C(Cl)C(OC)=C2)=NC3=CC=CC=C3C1=O
Molecular Weight 353,2
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.49
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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ISO Guide 34:2009

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