HNMPA

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HNMPA

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Cat No: 15543

Biochemicals - Kinase Inhibitors

HNMPA is a cell impermeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity.{25669} It does not affect protein kinase C or cyclic AMP-dependent protein kinase acti...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

P-(hydroxy-2-naphthalenylmethyl)-phosphonic acid

Correlated keywords:

120943-?99-?9 tyrosine kinase inhibitor phosphorylation insulin receptor signal transduction glucose uptake metabolism diabetes biochemical inhibit intracellular signaling protein biochemistry cell impermeable serine autophosphorylation 95-kDa ?-subunit ?subunit

Product Overview:
HNMPA is a cell impermeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity.{25669} It does not affect protein kinase C or cyclic AMP-dependent protein kinase activities.{25669} HNMPA inhibits the insulin-stimulated autophosphorylation of the 95-kDa β-subunit of the insulin receptor with an IC50 value of 200 µM in vitro.{25669}

Size	1 mg
Shipping	dry ice
CAS Number	132541-52-7
Molecular Formula	C₁₁H₁₁O₄P
SMILES	OC(P(O)(O)=O)C1=CC2=CC=CC=C2C=C1
Molecular Weight	238,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2909.60
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.