Herbimycin A

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Herbimycin A

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Cat No: 15504

Biochemicals - Kinase Inhibitors

Herbimycin A is a benzoquinone ansamycin antibiotic from Streptomyces.{25103} It has herbicidal activity and acts as a cell-permeable inhibitor of non-receptor tyrosine kinases and the heat shock protein Hsp90.{25103,25105,25109} Herbimycin A inhibits...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

17-demethoxy-15R-methoxy-11-O-methyl-geldanamycin

Correlated keywords:

1258005-?88-?7 natural product inhibitors inhibits inhibitions kinases proteins angiogenesis cancers cells cycles apoptosis tyrosines Hsps 90 Hsp90 Hsp-90 heat shock proteins 90 ansamycin antibiotic benzoquinone Streptomyces PKs PKA PKC Rac Myc Raf NSCs 305978 NSC305978 NSC-305978 TANs 420F 420 F herbimycin-A herbicidal cell-permeable permeable non-receptor non receptors Bcr-Abl scr yes fps ros erbb NF-kappaB NF-.kappa.B NF-kB NF-?B phosphorylation eggshell formations erbb2 client proteins HER2 HER 2

Product Overview:
Herbimycin A is a benzoquinone ansamycin antibiotic from Streptomyces.{25103} It has herbicidal activity and acts as a cell-permeable inhibitor of non-receptor tyrosine kinases and the heat shock protein Hsp90.{25103,25105,25109} Herbimycin A inhibits Bcr-Abl with an IC50 value of 5 μM, a concentration that also effectively blocks Src, Yes, Fps, Ros, and ErbB but not protein kinases (PK) PKA, PKC, Rac, Myc, or Raf.{25105,25112} Presumably through its effects on tyrosine kinase signaling, herbimycin A also impairs endothelial cell proliferation in the context of angiogenesis, NF-κB activation, phosphorylation of phospholipase C-γ1, and eggshell formation in schistosome parasites.{25113,25111,25104,25110} Ansamycins, including herbimycin A and geldanamycin (Item No. 13355), bind Hsp90 and destabilize client proteins, including Src, Bcr-Abl, and ErbB2, leading to their ubiquitination and proteasomal degradation.{25109,15573}

Size	500 µg
Shipping	dry ice
CAS Number	70563-58-5
Molecular Formula	C₃₀H₄₂N₂O₉
SMILES	O=C(C=C(C1=O)NC(/C(C)=C/C=C\[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@@H]([C@H]([C@H](C[C@@H]2C)OC)OC)C)=O)C=C1[C@@H]2OC
Molecular Weight	574,7
Formulation	A yellow lyophilisate
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.