Pitavastatin (calcium salt)

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Cat No: 15414

Biochemicals - Small Molecule Inhibitors

The statins are a family of compounds that inhibit 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase, a pivotal enzyme in cholesterol biosynthesis.{20936} Pitavastatin is a potent inhibitor of HMG-CoA reductase (Ki = 1.7 nM).{25250} It lowers ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid, hemicalcium salt

Correlated keywords:

147511-69-1 1187885-?60-?4 1187847-?92-?2 587840-28-6 3-hydroxy-3-methyl glutaryl coenzyme A ?-Hydroxy ?-methylglutaryl HMGCoA HMG CoA NKS104 NK104 NK-104 Nisvastatin

Product Overview:
The statins are a family of compounds that inhibit 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase, a pivotal enzyme in cholesterol biosynthesis.{20936} Pitavastatin is a potent inhibitor of HMG-CoA reductase (Ki = 1.7 nM).{25250} It lowers both total cholesterol and low density lipoprotein cholesterol in animals and humans.{25248} Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions.{25248} Moreover, pitavastatin causes atherosclerosis regression in humans with subclinical carotid atherosclerosis and improves cardiac function and survival in a rat model of hypertensive heart failure.{25249,25247}

Size	10 mg
Shipping	dry ice
CAS Number	147526-32-7
Molecular Formula	C₂₅H₂₃FNO₄ •1/2Ca
SMILES	[O-]C(C[C@H](O)C[C@H](O)/C=C/C1=C(C2=CC=C(F)C=C2)C3=C(C=CC=C3)N=C1C4CC4)=O.[Ca+2]
Molecular Weight	440,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.