Captopril

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Captopril

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Cat No: 15313

Biochemicals - Small Molecule Inhibitors

Captopril is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 23 nM for the rabbit lung enzyme).{42208,52244} It inhibits contractions in isolated guinea pig ileal segments induced by angiotensin I or bradykinin (IC50s = 23 and 3 nM, respect...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline

Correlated keywords:

70903-?77-?4 138452-?88-?7 225661-?74-?5 Capoten angio tensin neuro blastoma hyper tension acediur aceplus acepress acepril alopresin angiopril capoten capotril captohexal captolane captomax capton captoprilGP generis mepha ratiopharm captopril captotec cesplon dilabar facopril farcopril garranil hipertil hypopress L-captopril lopirin lopril lotensin novocaptopril S-captopril SA333 SQ14225 tensiomin tnesobon tensoprel zapto

Product Overview:
Captopril is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 23 nM for the rabbit lung enzyme).{42208,52244} It inhibits contractions in isolated guinea pig ileal segments induced by angiotensin I or bradykinin (IC50s = 23 and 3 nM, respectively) but not those induced by angiotensin II, histamine, acetylcholine, serotonin (5-HT), or prostaglandin E1 (PGE1; IC50s = >10 µM for all).{52244} Captopril (0.1-1 mg/kg) inhibits angiotensin I-induced pressor responses in conscious normotensive rats.{42208} It reduces mean blood pressure in two kidney-one clip renal hypertensive (2K-1C) rats and spontaneously hypertensive rats (SHRs). Captopril also reduces cytopathogenicity induced by herpes simplex virus 1 (HSV-1) in SH-SY5Y human neuroblastoma cells.{61145} Formulations containing captopril have been used in the treatment of hypertension, congestive heart failure, and diabetic nephropathy.

Size	1 g
Shipping	dry ice
CAS Number	62571-86-2
Molecular Formula	C₉H₁₅NO₃S
SMILES	OC([C@@H]1CCCN1C([C@H](C)CS)=O)=O
Molecular Weight	217,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.