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ML-098

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    ML-<wbr/>098
  • ML-<wbr/>098
Cat No: 15175
Biochemicals - Small Molecule Activators
Cayman

The Ras family of GTPases, including the Arf, Rho, Ras, and Rab GTPase subfamilies, regulates various cellular processes ranging from membrane trafficking to the control of cell proliferation. They regulate cell physiology by switching between active a...

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This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 1-[2-(2,5-dimethylphenoxy)ethyl]-1H-indole-3-carboxylic acid
Correlated keywords:
  • Molecular Libraries Initiative SIDs 57578337 SID-57578337 SID57578337 CID-7345532 CID7345532 CIDs 7345532 Ras GTPases GTP GDP nucleotide activators activates activating Rab7 Rab-7 Rabs 7 seven ML098 MLs 098 ML-98 ML98 98 GTP-binding GTPs binding binds binders cdc42 cdc-42 cdc 42 Rab-2A Rab2A Rabs 2A Racs 1 one Rac-1 guanine nucleotides selective signals transductions intracellular family Arf Rho subfamilies cellular processes regulates membrane trafficking control cells proliferations physiology switching active inactives conformational states alterations functions cancer genetic diseases ML-098 selectivity increasing affinity
Product Overview:
The Ras family of GTPases, including the Arf, Rho, Ras, and Rab GTPase subfamilies, regulates various cellular processes ranging from membrane trafficking to the control of cell proliferation. They regulate cell physiology by switching between active and inactive conformational states by binding either GTP or GDP. Alterations in GTPase function are a known hallmark of certain cancers and genetic diseases. ML-098 is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM) that demonstrates selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively).{24525} It has been shown to function by increasing the affinity of the GTPase for guanine nucleotides.{24525}
Size 1 mg
Shipping dry ice
CAS Number 878978-76-8
Molecular Formula C19H19NO3
SMILES CC1=CC=C(C)C(OCCN2C(C=CC=C3)=C3C(C(O)=O)=C2)=C1
Molecular Weight 309,4
Formulation A crystalline solid
Purity ≥98%
Custom Code 2918.99
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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