LCK Inhibitor

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LCK Inhibitor

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Cat No: 15135

Biochemicals - Kinase Inhibitors

Lymphocyte-speciﬁc protein tyrosine kinase (LCK) is a member of the Src-family of non-receptor protein tyrosine kinases and plays a critical role in the initial steps of T cell receptor signaling that trigger the production of cytokines.{24187} LCK inh...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Correlated keywords:

RK 24466 RK-24466 RK24466 lymphocytes specific lymphocyte-speci?c kinases Lck Src non-receptors nonreceptors non receptors proteins tyrosines kinases T-cells signaling cytokines lck IL-2 IL2 ILs 2 two interleukins signals transductions intracellular signaling inhibits inhibitions inhibitors immunology cytokines selective pyrrolopyrimidines lckcd

Product Overview:
Lymphocyte-speciﬁc protein tyrosine kinase (LCK) is a member of the Src-family of non-receptor protein tyrosine kinases and plays a critical role in the initial steps of T cell receptor signaling that trigger the production of cytokines.{24187} LCK inhibitor is a pyrrolopyrimidine that blocks the activity of two forms of LCK kinase, LCK (64-509) and LCKCD, with IC50 values of 50s = 70 nM, 1.57, and 1.98 µM, respectively) and only minimally inhibits the activities of EGFR, PKC, CDC2/B and ZAP-70 (IC50s = 3.2, >33, >50, and >50 µM, respectively).{24189,24188} This compound has been shown to inhibit T cell receptor-stimulated IL-2 production in mice (ED50s = 4 and 25 mg/kg when administered either i.p. or orally).{24189,24190}

Size	1 mg
Shipping	dry ice
CAS Number	213743-31-8
Molecular Formula	C₂₃H₂₂N₄O
SMILES	NC1=C2C(C(C=C3)=CC=C3OC4=CC=CC=C4)=CN(C5CCCC5)C2=NC=N1
Molecular Weight	370,5
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.49
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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