FFAR4 (GPR120) (N-Term) Polyclon

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FFAR4 (GPR120) (N-Term) Polyclonal Antibody

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Cat No: 15130

GPR120 is a G protein-coupled receptor (GPCR) expressed in adipocytes and pro-inflammatory macrophages that is activated by long chain free fatty acids.{13205} The activation of GPR120 results in elevated calcium ion and activation of the ERK cascade....

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

G-Protein coupled receptors free fatty acids ?-3 anti-inflammatory antinflammatory anti inflammatory insulin apoptosis G proteins antibodies GPRs GPR-120 120 GPCRs adipocytes macrophages long chains calcium ions Ca2+ ERKs docosahexaenoic eicosapentaenoic acids DHAs EPAs toll-like toll like TLRs TNF tumor necrosis factors insulin secretions enteroendocrin cells lines STC-1 STC1 STC 1 one LoVo PC3 PC-3 PCs three 3 western blots blotting WB N-term N terms ELISA enzyme-linked immunosorbent assays

Product Overview:
GPR120 is a G protein-coupled receptor (GPCR) expressed in adipocytes and pro-inflammatory macrophages that is activated by long chain free fatty acids.{13205} The activation of GPR120 results in elevated calcium ion and activation of the ERK cascade.{13205} ω-3 Fatty acids, such as docosahexaenoic acid and eicosapentaenoic acid initiate GPR120 signaling resulting in inhibition of toll-like receptor and TNF-α inflammatory signaling pathways in a β-arrestin2/TAB1 dependent manner.{22326} The anti-inflammatory effects of GPR120 are indirectly involved with promoting insulin secretion.{13205} GPR120 also mediates free fatty acid induced apoptosis inhibition in the enteroendocrin cell line STC-1.{13205} Cayman’s N-terminal polyclonal antibody detects GPR120 in LoVo and PC3 cell lysates. The predicted size for GPR120 is 42.2 kDa and the observed size is approximately 45 kDa by western blot.

Size	1 ea
Shipping	dry ice
Host	Rabbit
Antigen	Synthetic peptide from the N-terminal region of human FFAR4 (GPR120)
Application(s)	ELISA and WB
Formulation	500 µl of Peptide affinity-purified antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.