Probucol

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Probucol

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Cat No: 15043

Biochemicals - Ox Stress Reagents

Probucol is a potent antioxidant that inhibits the oxidation of cholesterol in LDL, which prevents the formation of macrophage-derived foam cells that lead to atherosclerotic vascular lesions.{24123} Probucol’s use is limited, however, because it lead...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4,4'-[(1-methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)-phenol

Correlated keywords:

antioxidants hypocholesterolemic cholesterol LDL HDL inhibitors inhibits inhibitions lipids peroxidation ATP-binding cassette transporters A1 ABCA1 atherosclerosis neuroprotective ATPs binding binds ABCA-1 ABCA 1 one ABCA-1 A-1 A low density lipoproteins high J774 J-774 J 774 macrophages plasma membranes huntingtons diseases biphenabid bisbid bisphenabid lipomal lurselle panavir phenbutol probucol sinlestal oxidative injury injuries inflammation inflammatory glutathione peroxidases neuroscience

Product Overview:
Probucol is a potent antioxidant that inhibits the oxidation of cholesterol in LDL, which prevents the formation of macrophage-derived foam cells that lead to atherosclerotic vascular lesions.{24123} Probucol’s use is limited, however, because it leads to the reduction of HDL cholesterol as well.{24123} Probucol inhibits up to 80% efflux of cholesterol from J774 macrophages by impairing the translocation of ATP-binding cassette transporter A1 from intracellular compartments to the plasma membrane.{24125} In an in vivo mouse model of Huntington’s disease, 3.5 mg/kg/day probucol was shown to be protective against behavioral and striatal oxidative damage by increasing the activity of glutathione peroxidase.{24124}

Size	5 g
Shipping	dry ice
CAS Number	23288-49-5
Molecular Formula	C₃₁H₄₈O₂S₂
SMILES	CC(C)(C)C1=CC(SC(C)(C)SC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)=CC(C(C)(C)C)=C1O
Molecular Weight	516,8
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.