Thymoquinone

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Thymoquinone

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Cat No: 15039

Biochemicals - Natural Products

The black seeds of Nigella have long been ingested to treat a broad range of diseases, including inflammation and cancer.{23958} Thymoquinone is a natural phytochemical isolated from the seeds of N. sativa.{23958} It has anti-inflammatory effects, bloc...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione

Correlated keywords:

natural products inhibitors inflammation cancers angiogenesis apoptosis inhibits inhibitions anticancer anti anti-cancers phytochemical seeds N. sativa nigella antiinflammatory anti-inflammatory inflammatory leukotrienes LTs inhibits leukemia cells STAT3 genes expressions NSCs 2228 NSC2228 NSC-228 thymoquinon

Product Overview:
The black seeds of Nigella have long been ingested to treat a broad range of diseases, including inflammation and cancer.{23958} Thymoquinone is a natural phytochemical isolated from the seeds of N. sativa.{23958} It has anti-inflammatory effects, blocking the synthesis of leukotrienes.{23955,23958} Thymoquinone inhibits the growth of leukemia cells (IC50 = 1.5 μg/ml), inducing apoptosis by down-regulating the expression of Bcl-2 while up-regulating Bax expression.{23957} In addition to blocking cell proliferation and triggering apoptosis, thymoquinone (15 μM) suppresses STAT3-regulated gene expression and prevents angiogenesis.{23959,23956}

Size	500 mg
Shipping	dry ice
CAS Number	490-91-5
Molecular Formula	C₁₀H₁₂O₂
SMILES	O=C(C(C(C)C)=C1)C=C(C)C1=O
Molecular Weight	164,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2912.49
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.