Meloxicam

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Meloxicam

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Cat No: 14906

Biochemicals - Small Molecule Inhibitors

Meloxicam is a selective inhibitor of COX-2 (IC50s = 11.8 and 143 μM for COX-2 and COX-1, respectively, in an enzyme activity assay) and a non-steroidal anti-inflammatory drug (NSAID).{5788} Meloxicam (0.03%) reduces croton oil-induced increases in TN...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-1,1-dioxide-2H-1,2-benzothiazine-3-carboxamide

Correlated keywords:

133687-22-6 non-steroidal non steroidal nonsteroidal anti inflammatory anti inflammatory antiinflammatory anti-inflammatory drugs NSAID COX-2 COX2 COXs COX1 COX-1 antiinflammatory antipyretic analgesic rheumatoid arthritis osteoarthritis gastrointestinal toxicity animal models inhibits inhibitors inhibitions acute exudation leukocyte migration prevents bone cartilage destruction selective coxflam maxciam melfax melonex metacam mobec Mobic mobicox movalis movatec revmoksikam cyclooxygenases one two inflammation IL10 TNF? IL1? E-2 PGE-2 Coxicam

Product Overview:
Meloxicam is a selective inhibitor of COX-2 (IC50s = 11.8 and 143 μM for COX-2 and COX-1, respectively, in an enzyme activity assay) and a non-steroidal anti-inflammatory drug (NSAID).{5788} Meloxicam (0.03%) reduces croton oil-induced increases in TNF-α and IL-1β mRNA levels and increases IL-10 mRNA levels in cornea in a rabbit model of acute ocular inflammation.{15890} It inhibits pleural plasma exudation in a carrageenan-induced rat model of pleurisy when administered at a dose of 3 mg/kg.{5788} In a canine model of unilateral osteoarthritis of the right stifle joint, meloxicam reduces prostaglandin E2 (PGE2) levels in plasma and right stifle joint synovial fluid when administered at a dose of 0.2 mg/kg.{13042} Formulations containing meloxicam have been used in the treatment of osteoarthritis and rheumatoid arthritis.

Size	25 mg
Shipping	dry ice
CAS Number	71125-38-7
Molecular Formula	C₁₄H₁₃N₃O₄S₂
SMILES	O=S1(C2=CC=CC=C2C(O)=C(C(NC3=NC=C(C)S3)=O)N1C)=O
Molecular Weight	351,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.