?-Truxillic Acid

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?-Truxillic Acid

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Cat No: 14865

Biochemicals - Small Molecule Inhibitors

α-Truxillic acid can be formed by the dimerization of two molecules of α-trans-cinnamic acid.{23826} It is related to incarvillateine, a natural antinociceptive compound derived from the Asian herb I. sinensis.{23827} α-Truxillic acid and some of its ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(1?,2?,3?,4?)-2,4-diphenyl-1,3-cyclobutanedicarboxylic acid

Correlated keywords:

4462-95-7 inflammation pains arthritis neuroscience .alpha.-trans-cinnamic acids ?-trans-cinnamic a-trans-cinnamic incarvillateine antinociceptives inflammatory fatty bindings proteins 5 five FABP5 anandamides a-Truxillic alpha-Truxillic .alpha.-Truxillic a alpha .alpha. anti-nociceptives anti nociceptives FABPs FABP-5 blocks neurogenic PPAR-? PPARg SB-FI-26 PPAR-g SBF126 PPARgamma PPAR-gamma SB FI 26 PPAR? ? gamma g PPAR.gamma. PPAR-.gamma. PPA .gamma. peroxisome proliferator-activated proliferator activated

Product Overview:
α-Truxillic acid can be formed by the dimerization of two molecules of α-trans-cinnamic acid.{23826} It is related to incarvillateine, a natural antinociceptive compound derived from the Asian herb I. sinensis.{23827} α-Truxillic acid and some of its derivatives significantly block inflammatory pain while having little effect on neurogenic pain, as indicated by the formalin test in mice.{23827,23828} Related compounds, like SB-FI-26 (Item No. 14191), bind fatty acid binding protein 5 (FABP5).{22111} This may be related to pain suppression, since FABP5 acts as a transporter of the endocannabinoid anandamide.{17092} While certain derivatives of α-truxillic acid can directly activate peroxisome proliferator-activated receptor γ, α-truxillic acid has no such activity.{23829}

Size	10 mg
Shipping	dry ice
CAS Number	490-20-0
Molecular Formula	C₁₈H₁₆O₄
SMILES	OC([C@H]1[C@H](C2=CC=CC=C2)[C@H](C(O)=O)[C@H]1C3=CC=CC=C3)=O
Molecular Weight	296,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2918.99
UNSPSC code	12352100

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MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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