Nafamostat (mesylate)

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Cat No: 14837

Biochemicals - Small Molecule Inhibitors

Nafamostat is a serine protease inhibitor that is capable of inhibiting trypsin (a digestive system protease; Ki = 15 nM), tryptase (a mast cell protease; Ki = 95.3 pM), and additional proteases in the coagulation cascade including thrombin (Ki = 0.84...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[(aminoiminomethyl)amino]-benzoic acid, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate

Correlated keywords:

81525-10-12 mesilate serines protease inhibitors inhibits inhibitions anticoagulant trypsin tryptase inflammation asthma digestive system protease mast cells coagulation cascade thrombin allergic asthma serine proteolytic active activity decrease circulating levels eosinophils lymphocytes bronchoalveolar lavage fluids reduce IL-13 interleukins 13 IL13 ILs eotaxin production antigen-induced antigen induced airways eosinophilia goblet cells hyperplasia FUT175 FUT-175 FUTs 175 coahibitors allergy allergies

Product Overview:
Nafamostat is a serine protease inhibitor that is capable of inhibiting trypsin (a digestive system protease; Ki = 15 nM), tryptase (a mast cell protease; Ki = 95.3 pM), and additional proteases in the coagulation cascade including thrombin (Ki = 0.84 μM).{23663} In a mouse model of allergic asthma, a dose of 300 mg/kg nafamostat mesylate has been shown to inhibit serine proteolytic activity, to decrease circulating levels of eosinophils and lymphocytes in bronchoalveolar lavage fluid, and to reduce interleukin-13 and eotaxin production associated with antigen-induced airway eosinophilia and goblet cell hyperplasia.{23662}

Size	5 mg
Shipping	dry ice
CAS Number	82956-11-4
Molecular Formula	C₁₉H₁₇N₅O₂ • 2CH₃SO₃H
SMILES	NC(C1=CC=C2C(C=CC(OC(C3=CC=C(NC(N)=N)C=C3)=O)=C2)=C1)=N.CS(=O)(O)=O.CS(=O)(O)=O
Molecular Weight	539,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.