Ibudilast

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Ibudilast

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Cat No: 14832

Biochemicals - Small Molecule Inhibitors

Ibudilast is an inhibitor of phosphodiesterase 4 (PDE4; IC50s = 54, 65, 239, and 166 nM for PDE4A-D, respectively).{23596} It is selective for PDE4 over PDE1, PDE7A, PDE7B, and PDE9A (IC50s = ≥10,000 nM for all) but does inhibit PDE3A, PDE3B, and PDE5...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone

Correlated keywords:

PDE 4 4A PDE4AD 1 7B 9A 3A 3B 5A TNF? MLP LTB IL6 IL1? MP TP GD NF AV411 KC404

Product Overview:
Ibudilast is an inhibitor of phosphodiesterase 4 (PDE4; IC50s = 54, 65, 239, and 166 nM for PDE4A-D, respectively).{23596} It is selective for PDE4 over PDE1, PDE7A, PDE7B, and PDE9A (IC50s = ≥10,000 nM for all) but does inhibit PDE3A, PDE3B, and PDE5A (IC50s = 1,600, 2,700, and 3,510 nM, respectively). Ibudilast inhibits LPS-induced production of TNF-α and fMLP-induced production of leukotriene B4 (LTB4; Item No. 20110) in isolated human whole blood (IC50s = 6.2 and 2.5 μM, respectively). It inhibits bronchospasm by 34% in a guinea pig model of leukotriene-mediated allergic bronchospasm when administered intravenously at a dose of 5 mg/kg.{47641} Ibudilast prevents increases in TNF-α, IL-1β, and IL-6 expression in the striatum in a mouse model of MPTP-induced Parkinson's disease.{47642} It also increases striatal expression of glial cell-derived neurotrophic factor (GDNF) in MPTP-treated and -untreated mice when administered at doses of 40 and 50 mg/kg, respectively, twice per day.

Size	5 mg
Shipping	dry ice
CAS Number	50847-11-5
Molecular Formula	C₁₄H₁₈N₂O
SMILES	CC(C)C1=NN(C=CC=C2)C2=C1C(C(C)C)=O
Molecular Weight	230,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.29
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.