W-7 (hydrochloride)

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W-7 (hydrochloride)

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Cat No: 14826

Biochemicals - Kinase Inhibitors

Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function.{23723,23722} W-7 is a cell-permeable antagonist of calmodulin (Ki = 11 μM...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, monohydrochloride

Correlated keywords:

65595-90-6 inhibits cells permeable antagonists W7 Ws 7 seven binds bindings binder domains proteins calcium-binding calcium troponin C myosin light chains kinases HCl cell-permeable calmodulin NSCs 683545 NSC-683545 NSC683545 inhibitions

Product Overview:
Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function.{23723,23722} W-7 is a cell-permeable antagonist of calmodulin (Ki = 11 μM).{23720,22382} Two molecules of W-7 bind to calcium-binding domains in each calmodulin molecule, blocking its interaction with target proteins.{23720} W-7 also associates, at lower affinities, with calcium-binding domains of other proteins, including troponin C and myosin light chain kinase (Ki = 70 and 300 μM, respectively).{23724,23721,23719}

Size	10 mg
Shipping	dry ice
CAS Number	61714-27-0
Molecular Formula	C₁₆H₂₁ClN₂O₂S • HCl
SMILES	ClC1=C(C=CC=C2S(NCCCCCCN)(=O)=O)C2=CC=C1.Cl
Molecular Weight	377,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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