R-848

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R-848

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Cat No: 14806

Biochemicals - Anti-Infection

R-848 is an immune response modifier that mimics the pathogen-associated molecular patterns that activate immune cells through Toll-like receptor 7 (TLR7) and TLR8. It demonstrates potent anti-tumor and anti-viral properties and has been used to study...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-amino-2-(ethoxymethyl)-?,?-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol

Correlated keywords:

171742-32-8 208711-44-8 resiquimod S-28463 antiviral toll-like receptors tolls like TLR-7 TLR-8 seven eight TLRs TLR7 TLR8 immunes responses anti-tumor anti-viral innates immunity cytokines inductions ligands anti virals tumors R848 R 848 S28463 S 28463 infectious diseases immunology agonists cancers 7s 8s modifiers mimics pathogen-associated molecular patterns pathogens associated activates cells infections CD40-induced Bs CD40 induced activations induces productions IFN-? IFN-gamma IFN-.gamma. IFN gamma ?

Product Overview:
R-848 is an immune response modifier that mimics the pathogen-associated molecular patterns that activate immune cells through Toll-like receptor 7 (TLR7) and TLR8. It demonstrates potent anti-tumor and anti-viral properties and has been used to study the innate immune response to viral infections. {23569,23568,23572} At 1 μg/ml, R-848 mimics CD40-induced B cell activation and can be used to induce the production of IFN-γ and various other cytokines.{23570,23571}

Size	5 mg
Shipping	dry ice
CAS Number	144875-48-9
Molecular Formula	C₁₇H₂₂N₄O₂
SMILES	NC1=NC2=CC=CC=C2C3=C1N=C(COCC)N3CC(C)(C)O
Molecular Weight	314,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.