SU 9516

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SU 9516

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Cat No: 14796

Biochemicals - Kinase Inhibitors

SU 9516 is a 3-substituted indolinone that has anti-proliferative and pro-apoptotic activity in tumor cells. It is a potent inhibitor of several cyclin-dependent kinases (CDKs) with selectivity for Cdk2 (IC50s = 22, 40, and 200 nM for Cdk2/cyclin A, C...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1,3-dihydro-3Z-(1H-imidazol-5-ylmethylene)-5-methoxy-2H-indol-2-one

Correlated keywords:

Cdk2 apoptosis cancers cyclins inhibitors leukemias pRb retinoblastomas proteins cells cycles SU9516 SU-9516 SU 9515 3-substituted indolinones 3 substituted anti-proliferatives anti proliferatives antiproliferatives pro-apoptotic proapoptotic pro apoptotic activity activities active tumors cyclin-dependent dependent kinases CDKs Cdk-2 2 two Cdk1 Cdk-1 1 one A B D1 cyclin-D1 cyclin-A cyclin-B retinoblastomas pRb cell-cycles arrests U-937 U 937 U937 jurkat HL-60 HL60 HL 60 Mcl1 Mcl-1 Mcl 1 mitochondrial mitochondrias injuries injury deaths inhibits inhibitions Cdk4 Cdk-4 4 Cdk2/cyclin Cdk1/cyclin Cdk4/cyclin 3 three substituted PKC p38 PDGFR EGFR phosphorylations pRb/E2F complexes formations downregulates downregulation transcriptions

Product Overview:
SU 9516 is a 3-substituted indolinone that has anti-proliferative and pro-apoptotic activity in tumor cells. It is a potent inhibitor of several cyclin-dependent kinases (CDKs) with selectivity for Cdk2 (IC50s = 22, 40, and 200 nM for Cdk2/cyclin A, Cdk1/cyclin B, and Cdk4/cyclin D1).{23507} It does not inhibit PKC, p38, PDGFR, or EGFR (IC50s = >10 µM).{23507} SU 9516 inhibits phosphorylation of the retinoblastoma protein pRb, resulting in increased pRb/E2F complex formation, cell-cycle arrest, and subsequent apoptosis.{23507,23508} In leukemia cells (U937, Jurkat, and HL-60 cells) SU 9516 downregulates transcription of the antiapoptotic protein Mcl-1, leading to mitochondrial injury and cell death.{23509}

Size	1 mg
Shipping	dry ice
CAS Number	377090-84-1
Molecular Formula	C₁₃H₁₁N₃O₂
SMILES	O=C1NC2=CC=C(OC)C=C2/C1=C/C3=CNC=N3
Molecular Weight	241,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.