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BAY 11-7085

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    BAY 11-<wbr/>7085
  • BAY 11-<wbr/>7085
Cat No: 14795
Biochemicals - Small Molecule Inhibitors
Cayman

In the classical pathway of NF-κB activation, phosphorylation of the inhibitor of NF-κB (IκBα) releases the inhibitor from NF-κB, allowing IκBα degradation and NF-κB activation and nuclear import.{19822} BAY 11-7085 is an irreversible inhibitor of IκBα...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2E-propenenitrile
Correlated keywords:
  • inhibits inhibitions inhibitors NF-kB apoptosis inflammation nuclear receptors signals transduction intracellular signaling BAYs 117085 11 7085 BAY-11-7085 BAY11-7085 BAY-117085 BAY117085 BAY11 BAY-11 irreversible I?B? IkBa IkappaBalpha I.kappa.B.alpha. NF-?B NF-kB NF-.kappa.B NF-kappaB genes expressions blocks blockages cells adhesions 117083 phosphorylation cytokines lipopolysaccharides activates activations
Product Overview:
In the classical pathway of NF-κB activation, phosphorylation of the inhibitor of NF-κB (IκBα) releases the inhibitor from NF-κB, allowing IκBα degradation and NF-κB activation and nuclear import.{19822} BAY 11-7085 is an irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM).{16037} It blocks gene expression that is regulated through the classical pathway of NF-κB activation and in this way blocks apoptosis, cell adhesion, and inflammation.{16037,24580,24840} BAY 11-7085 is also used to study IκBα actions that are independent of NF-κB signaling.{24581}
Size 5 mg
Shipping dry ice
CAS Number 196309-76-9
Molecular Formula C13H15NO2S
SMILES CC(C)(C)C1=CC=C(S(/C=C/C#N)(=O)=O)C=C1
Molecular Weight 249,3
Formulation A crystalline solid
Purity ≥98%
Custom Code 2930.90
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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