25(S)-27-hydroxy Cholesterol

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Cat No: 14791

Biochemicals - Lipids

The liver x receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism.{12040} 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated chol...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(25S)-cholest-5-ene-3?,26-diol

Correlated keywords:

livers X receptors LXR? LXR? LXRalpha LXRbeta LXR.alpha. LXR.beta. LXRa LXRb LXR-alpha LXR-beta LXR-.alpha. LXR-.beta. LXR-a LXR-b a b alpha beta .beta. .alpha. ? ? oxysterol cholesterol lipids metabolism agonist nuclear receptors atherosclerosis 27-hydroxycholesterol 26-hydroxycholesterol CYP27 CYPs CYP-27 27 cholesterols hydroxy 27 26 endogenous agonist fatty acids metabolism activates active potent suppressors steroids oxysterols (25S)-cholest-2-ene-3b,26-diol

Product Overview:
The liver x receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism.{12040} 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRα and LXRβ in vitro with EC50 values of 85 and 71 nM, respectively, and is a potent suppressor of cholesterol biosynthesis.{13891,23747} 25(S)-27 hydroxy Cholesterol is the less predominant-occurring (~20%) stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol.{23746,23745}

Size	1 mg
Shipping	dry ice
CAS Number	56845-83-1
Molecular Formula	C₂₇H₄₆O₂
SMILES	O[C@@H]1CC2=CC[C@]3([H])[C@@](CC[C@]4([C@@]3([H])CC[C@]4([H])[C@@H](CCC[C@H](C)CO)C)C)([H])[C@](C)2CC1
Molecular Weight	402,7
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2937.29
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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