AMPK activator

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AMPK activator

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Cat No: 14741

Biochemicals - Small Molecule Activators

AMPK activator is an indirect activator of AMP-activated protein kinase, AMPK (EC50 = 11.7 μM).{23464} It is thought to activate AMPK by inhibiting mitochondrial complex I, producing an increase in AMP levels.{23464} AMPK activator stimulates glucose ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-[3-[4-[2-(4-fluorophenyl)ethoxy]phenyl]propyl]-2-furancarboxylic acid

Correlated keywords:

diabetes cancers signals transductions cells permeable activates activators AMPs proteins kinases inhibits inhibitors mitochondrial complex I uptake up-take up-takes phosphorylation acetyl-CoA carboxylase myeloma prostates mTORC1 signaling survivin L6 myocytes blood glucose Zucker rats PC3

Product Overview:
AMPK activator is an indirect activator of AMP-activated protein kinase, AMPK (EC50 = 11.7 μM).{23464} It is thought to activate AMPK by inhibiting mitochondrial complex I, producing an increase in AMP levels.{23464} AMPK activator stimulates glucose uptake in L6 myocytes and promotes phosphorylation of acetyl-CoA carboxylase, a known target of AMPK.{23464} AMPK activator also decreases blood glucose concentrations in female Zucker diabetic rats, demonstrating its utility in whole animals.{23464} At 50 μM, it inhibits the growth of multiple myeloma cells.{23463} AMPK activator induces phosphorylation of raptor in PC3 prostate cancer cells, down-regulating mTORC1 signaling and reducing survivin expression.{23465}

Size	1 mg
Shipping	dry ice
CAS Number	849727-81-7
Molecular Formula	C₂₂H₂₁FO₄
SMILES	FC1=CC=C(CCOC2=CC=C(CCCC3=CC=C(C(O)=O)O3)C=C2)C=C1
Molecular Weight	368,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2903.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.