G-15 - C19H16BrNO2 - Bertin Bioreagent

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G-15

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Cat No: 14673

Biochemicals - Receptor Pharmacology

G protein-coupled estrogen receptor (GPER), or GPR30, specifically binds natural and man-made estrogens.{23445} It is thought to be involved in estrogen-sensitive cancers.{23445,23446} GPER knockout mice are fertile, although they exhibit thymic atroph...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3aS,4R,9bR)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

Correlated keywords:

receptors antagonist cancers diabetes bones-related research bones related GPER g protein coupled estrogen protein-coupled GPR30 GPR-30 GPRs 30 non-steroidal nonsteroidal non steroidal antagonists estrogens ERs G15 Gs 15 G-15 antidepressive anti depressive anti-depressive in vivo

Product Overview:
G protein-coupled estrogen receptor (GPER), or GPR30, specifically binds natural and man-made estrogens.{23445} It is thought to be involved in estrogen-sensitive cancers.{23445,23446} GPER knockout mice are fertile, although they exhibit thymic atrophy, impaired glucose tolerance, and altered bone growth.{23445} G-15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM).{23444} It displays low affinity cross-reactivity with the classical estrogen receptor (ER), ERα, so that at doses greater than 1 µM it is capable of mediating limited ER-dependent transcriptional activity.{23443} G-15 antagonizes the anti-depressive effects of estrogen in vivo.{23444}

Size	1 mg
Shipping	dry ice
CAS Number	1161002-05-6
Molecular Formula	C₁₉H₁₆BrNO₂
SMILES	BrC1=CC2=C(OCO2)C=C1[C@@H]3NC(C=CC=C4)=C4[C@@]5([H])[C@]3([H])CC=C5
Molecular Weight	370,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.49
UNSPSC code	12352100

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MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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