Clemastine (fumarate)

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Cat No: 14637

Biochemicals - Receptor Pharmacology

Clemastine is a selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity for muscarinic receptors (Ki = 16 nM).{23214} It has also recently been identified as a positive allosteric modulator of P2X7 receptor signaling...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

?(2R)-2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-pyrrolidine, 2E-butenedioate?

Correlated keywords:

52205-67-1 15686-51-8 meclastin antihistamines anti-histamines anti histamines H1 receptors antagonists muscarinic P2X7 bronchoconstriction asthma airways hyperresponsiveness allosteric signaling inhibits inhibitors inhibitions agasten aloginan alphamin anhistan bravegly hydrogen fuluminol HS 592 HS592 HS-592 unbestan kinotomin lacretin lecasol maikohis mallermin F mallermin-F marsthine masletine meclastine mecloprodine piloral reconin tavegil tavegyl tavist telgin telgin-G Gs trabest xolamin neurosciences inflammation allergy asthma purinoceptor genes

Product Overview:
Clemastine is a selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity for muscarinic receptors (Ki = 16 nM).{23214} It has also recently been identified as a positive allosteric modulator of P2X7 receptor signaling.{23212} Clemastine has long been used to inhibit histamine-induced bronchoconstriction in asthma and airway hyperresponsive studies.{23213}

Size	100 mg
Shipping	dry ice
CAS Number	14976-57-9
Molecular Formula	C₂₁H₂₆ClNO • C₄H₄O₄
SMILES	ClC1=CC=C([C@@](OCC[C@H]2CCCN2C)(C)C3=CC=CC=C3)C=C1.OC(/C=C/C(O)=O)=O
Molecular Weight	460
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.