Philanthotoxin 74 (hydrochloride

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Philanthotoxin 74 (hydrochloride)

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Cat No: 14607

Biochemicals - Ion Channel Modulation

Philanthotoxin 74 (PhTx-74) is a synthetic analog of the naturally-occurring wasp venom toxin philanthotoxin-4,3,3. It is a subtype-selective AMPA receptor antagonist that inhibits homomeric GluR1 and GluR3 as well as heteromeric GluR1/2 receptors (80...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[7-[(4-aminobutyl)amino]heptyl]-4-hydroxy-?S-[(1-oxobutyl)amino]-benzenepropanamide, dihydrochloride

Correlated keywords:

401601-12-5 toxins PhTx-74 PhTx74 glutamates receptors AMPA GluR1 GluR2 GluR1/2 GluR2/3 GluR5(Q) AMPA PhTx74 PhTX 74 analogs natural naturally wasps venom homomeric inhibits inhibitions inhibitors synthetics hydrochloride HCl philanthotoxin-74 GluRs GluR-1 GluR-2 GluR-1/2 GluR-2/3 GluR-5 1 2 5 ½ 2/3 neuroscience signals transductions receptors antagonists monomeric heteromeric

Product Overview:
Philanthotoxin 74 (PhTx-74) is a synthetic analog of the naturally-occurring wasp venom toxin philanthotoxin-4,3,3. It is a subtype-selective AMPA receptor antagonist that inhibits homomeric GluR1 and GluR3 as well as heteromeric GluR1/2 receptors (80-100% of glutamate-evoked currents inhibited at 100 µM). It exhibits minimal to no effect on monomeric GluR2 or heteromeric GluR2/3 receptors at concentrations up to 500 µM.{23500} PhTx-74 inhibits the GluR5(Q) receptor with a Ki value of 0.29 µM.{23501}

Size	1 mg
Shipping	room temp.
CAS Number	1227301-51-0
Molecular Formula	C₂₄H₄₂N₄O₃ • 2HCl
SMILES	OC1=CC=C(C[C@H](NC(CCC)=O)C(NCCCCCCCNCCCCN)=O)C=C1.Cl.Cl
Molecular Weight	507,5
Formulation	A solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.