Stattic

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Stattic

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Cat No: 14590

Biochemicals - Small Molecule Inhibitors

Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that convey signals from the cell membrane to the nucleus. In various human tumors, STAT3 is constitutively activated by aberrant upstre...

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About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

6-nitro-1,1-dioxide-benzo[b]thiophene

Correlated keywords:

signals transducers activators transcriptions factors STAT3 tumors cancers inhibitors inhibits inhibitions STAT-3 3 three inhibitory compounds small molecules activation activates active dimerization nuclear translocation prevents preventing binding binds binders tyrosine-phosphorylated peptides motifs SH2 SH-2 SHs 2 domains breasts MDA-MB-231 MDA-Mb-435S cells lines latent cytoplasmic signaling membranes nucleus humans aberrant upstream apoptosis induces STAT three inhibitory compounds MB4355 MB 4355

Product Overview:
Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that convey signals from the cell membrane to the nucleus. In various human tumors, STAT3 is constitutively activated by aberrant upstream tyrosine kinase activities.{23053} Stattic is a small molecule inhibitor of STAT3.{23053} It selectively inhibits STAT3 activation, dimerization, and nuclear translocation by preventing the binding of tyrosine-phosphorylated peptide motifs to the STAT3 SH2 domain (IC50 = 5.1 μM at 37°C).{23053} At 10 μM, stattic induces apoptosis in STAT3-dependent breast cancer (MDA-MB-231 and MDA-MB-435S) cell lines.{23053}

Size	10 mg
Shipping	dry ice
CAS Number	19983-44-9
Molecular Formula	C₈H₅NO₄S
SMILES	O=S1(C2=CC([N+]([O-])=O)=CC=C2C=C1)=O
Molecular Weight	211,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.