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Diazoxide

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    Diazoxide
  • Diazoxide
Cat No: 14576
Biochemicals - Ion Channel Modulation
Cayman

Diazoxide is an activator of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = 14.1 µM in a FLIPR assay using HEK293 cells).{36318} It also activates SUR2A/Kir6.2 and SUR2B/Kir6.2 channels in HEK293T cells in a pa...

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: 100 mg

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 7-chloro-3-methyl-1,1-dioxide-2H-1,2,4-benzothiadiazine
Correlated keywords:
  • 1342899-70-0 cardioprotection potassium channels agonists activators activations activates smooth muscles relaxation relax vasodilators hypertensions insulins membranes permeability permeables ions aortas rings decreases secretions hypoglycemia eudemine injections hyperstats hypertonalum mutabase proglicem proglycem Sch 6783 Sch-6783 Sch6783 NSCs 64198 76130 NSC-64198 NSC-76130 NSC64198 NSC76130 SRG-95213 SRG95213 SRGs 95213 K+ cells cellular releases voltages voltage-gated gates gated APs actions potentials rats hearts pancreas pancreatic beta b .beta. ? diseases
Product Overview:
Diazoxide is an activator of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = 14.1 µM in a FLIPR assay using HEK293 cells).{36318} It also activates SUR2A/Kir6.2 and SUR2B/Kir6.2 channels in HEK293T cells in a patch-clamp assay when used at concentrations of 30 and 300 µM.{48765} Diazoxide inhibits glucose-induced insulin release from isolated rat pancreatic β cells and induces relaxation of isolated rat aortic rings precontracted with potassium chloride (IC50s = 22.6 and 22.4 µM, respectively).{48766} It reduces mean arterial pressure and cerebral blood flow in spontaneously hypertensive rats when administered intravenously as a 5 mg/kg bolus dose.{48767} Diazoxide (50 mg/kg, i.p.) increases blood glucose levels in mice.{48768} Formulations containing diazoxide have been used in the treatment of hypoglycemia.
Size 100 mg
Shipping dry ice
CAS Number 364-98-7
Molecular Formula C8H7ClN2O2S
SMILES ClC1=CC=C2C(S(NC(C)=N2)(=O)=O)=C1
Molecular Weight 230,7
Formulation A crystalline solid
Purity ≥99%
Custom Code 2903.99
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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