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ML-228

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    ML-<wbr/>228
  • ML-<wbr/>228
Cat No: 14568
Biochemicals - Small Molecule Activators
Cayman

The hypoxia-inducible factor (HIF) transcription factors are members of the basic-helix-loop-helix (bHLH) family of transcription factors and play important roles in maintaining cellular oxygen homeostasis.{11044,12428} HIF-1α has emerged as an import...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • N-([1,1'-biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine
Correlated keywords:
  • hypoxia signals transduction HIF pathways hypoxia-inducible inducible factors oxygen MLs 228 ML228 signaling responses elements HRE reporters assays HIF-1? HIF-1.alpha. HIF-1alpha HIF-1a nuclear translocation assays VEGF expressions chelates iron inhibits inhibitors inhibitions ligands binding CID46742353 CID-46742353
Product Overview:
The hypoxia-inducible factor (HIF) transcription factors are members of the basic-helix-loop-helix (bHLH) family of transcription factors and play important roles in maintaining cellular oxygen homeostasis.{11044,12428} HIF-1α has emerged as an important drug target in breast and prostate cancer, cardiovascular disease, and ischemia.{10724,11835} ML-228 is an activator of the HIF signaling pathway, as demonstrated by HIF response element (HRE) reporter assay (EC50 = 1.2 µM), HIF-1α nuclear translocation assay (EC50 = 1.3 µM), and increased VEGF expression (EC50 = 1.6 µM).{23099} Its activity in the HRE assay is blocked by excess iron, suggesting that ML-228 can chelate iron.{23099} Molecular modeling indicates that ML-228 does not modulate HIF signaling by binding to prolyl hydroxyases.{23099} ML-228 also significantly inhibits ligand binding to several channels, receptors, and transporters, including ERG potassium channel, 5-HT2B and A3 adenosine receptors, and dopamine transporter.{23099}
Size 1 mg
Shipping dry ice
CAS Number 1357171-62-0
Molecular Formula C27H21N5
SMILES C1(C2=NC(NCC3=CC=C(C4=CC=CC=C4)C=C3)=C(C5=CC=CC=C5)N=N2)=NC=CC=C1
Molecular Weight 415,5
Formulation A crystalline solid
Purity ≥95%
Custom Code 2933.49
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cross selling for this product : ML-<wbr/>228 There are 2 products.

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