Chetomin

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Chetomin

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Cat No: 14437

Biochemicals - Natural Products

Chetomin is a natural product isolated from Chaetomium species which has antibacterial and antifungal properties.{22491} It is a small molecule inhibitor of hypoxia-inducible factor (HIF) signaling, disrupting the binding of HIF-1α and HIF-2α to p300 ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2,3S,5aR,6,10bS,11-hexahydro-3-(hydroxymethyl)-10b-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-3,11aS-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione

Correlated keywords:

hypoxia cancers inhibitors inhibits inhibitions chaetomium species antibacteriasl antifungals anti-bacterials anti bacterials bacteria anti-fungals fungal fungus hypoxia-inducible factors HIFs signals signaling cells growths grow tumors xenografts 1390-81-4 35808-58-3 NSC289491 NSC-289491 natural products smal molecules binds bindings HIF-1? HIF-1a HIF-1alpha HIF-1.alpha. HIF-2? HIF-2a HIF-2alpha HIF-2.alpha. p300 attenuates attenuations pathways in vivo mice mouse HIF-dependent

Product Overview:
Chetomin is a natural product isolated from Chaetomium species which has antibacterial and antifungal properties.{22491} It is a small molecule inhibitor of hypoxia-inducible factor (HIF) signaling, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.{22490} Chetomin effectively attenuates the HIF pathway both in cells and in vivo, in mice.{22490} It inhibits HIF-dependant signaling, cell growth, and tumor growth in cancer cells and xenografts.{22490,22489}

Size	1 mg
Shipping	dry ice
CAS Number	1403-36-7
Molecular Formula	C₃₁H₃₀N₆O₆S₄
SMILES	O=C(C1(CC2=CN([C@@]34C5=CC=CC=C5N[C@]3([H])N(C([C@@]6(CO)N(C)C7=O)=O)[C@]7(SS6)C4)C8=C2C=CC=C8)N9C)N(C)[C@@](CO)(SS1)C9=O
Molecular Weight	710,9
Formulation	An crystalline solid
Purity	≥95%
Custom Code	2930.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.