5-(N-ethyl-N-isopropyl)-Amilorid

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5-(N-ethyl-N-isopropyl)-Amiloride

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Cat No: 14406

Biochemicals - Transporter & Exchanger Modulators

Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N-ethyl-N-isopropyl)-Amiloride (EIPA) is a potent inh...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide

Correlated keywords:

inhibits inhibitions inhibitors ions channels pumps blockers exchangers sodiums Na+ H+ Na+/H+ selective ethyl isopropyls hydrogens sodium-hydrogen NHEs pH balance tissues antiporters anti-porters anti porters APNH solutes carriers family 9 SLC9 SLC-9 SLC 9 isoforms NHE1 NHE2 NHE3 NHE4 NHE5 NHE-1 NHE-2 NHE-3 NHE-4 NHE-5 1 2 3 4 5 EIPA cells cellular activity activities amiloride L593754 L-593754 L 593754 MH-12-43 MH12-43 MH 12-43

Product Overview:
Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N-ethyl-N-isopropyl)-Amiloride (EIPA) is a potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 μM, respectively.{22706,22708} It less effectively inhibits NHE4 (IC50 ≥10 μM).{22706} EIPA is commonly used at a concentration of 5-10 μM to inhibit cellular HNE activity.{22705,22707}

Size	5 mg
Shipping	dry ice
CAS Number	1154-25-2
Molecular Formula	C₁₁H₁₈ClN₇O
SMILES	ClC1=C(N(CC)C(C)C)N=C(N)C(C(NC(N)=N)=O)=N1
Molecular Weight	299,8
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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