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Tanshinone IIA

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    Tanshinone IIA
  • Tanshinone IIA
Cat No: 14323
Biochemicals - Small Molecule Inhibitors
Cayman

Tanshinone IIA (TSA) is a major lipophilic component of extracts from the root of S. miltiorrhiza, used widely in Chinese herbal medicine. It has anti-inflammatory activity, inhibiting production of TNF-α, IL-1β, IL-6, NO, INFγ, and expression of iNOS...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 6,7,8,9-tetrahydro-1,6,6-trimethyl-phenanthro[1,2-b]furan-10,11-dione
Correlated keywords:
  • inflammation cancers cytotoxic TNF? IL-1? IL-6 NO INF? iNOSIl-12 smooth muscle migration signal transduction Akt ERK tumors necrosis factors salvia miltoiorrhiza s. Chinese herbal medicines anti-inflammatory antiinflammatory anti inflammatory active activity interferes inhibits inhibitors inhibitions MMP-9 MMP9 MMP9 natural products anti-cancer anticancer TNFa TNFalpha TNF.alpha. TNF? alpha .alpha. a ? TNF-a TNF-alpha TNF-.alpha. TNF-? ILs interleukin IL-1 IL-6 IL-12 IL1 IL6 IL12 1 6 12 interelukin-1 interleukin-6 interleukin-12 IL-1beta IL-1b IL-1.beta. NO INFg INFgamma INF.gamma. INF-gamma INF-g INF-.gamma. INFs gamma .gamma. g ? INF-? INF? NQO1 ROS-mediated reactive oxygen speciese apoptotic cells deaths ROS NSCs 686518 686519 NSC-686518 NSC-686519 NSC686518 NSC686519 dan shen ketones tanshinons tanshinone-II tanshinone-B tanshinone-IIA B II A IIA apoptosis vascular diseases
Product Overview:
Tanshinone IIA (TSA) is a major lipophilic component of extracts from the root of S. miltiorrhiza, used widely in Chinese herbal medicine. It has anti-inflammatory activity, inhibiting production of TNF-α, IL-1β, IL-6, NO, INFγ, and expression of iNOS, and IL-12.{23549,23547} It blocks human aortic smooth muscle cell migration, inhibits MMP-9 activity, and interferes with PI3K/Akt and ERK1/2 signaling pathways.{23548} It is cytotoxic to various cancer cells including A549 lung cancer cells and leukemia cells.{23545,23544}Reduction of TSA by NAD(P)H:quinone oxidoreductase (NQO1) generates an unstable intermediate resulting in reactive oxygenase species-mediated apoptotic cell death.{23546}
Size 5 mg
Shipping dry ice
CAS Number 568-72-9
Molecular Formula C19H18O3
SMILES CC1=COC(C2=C3C4=C(C=C2)C(C)(C)CCC4)=C1C(C3=O)=O
Molecular Weight 294,3
Formulation A crystalline solid
Purity ≥97%
Custom Code 2932.99
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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