Thiazovivin

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Thiazovivin

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Cat No: 14245

Biochemicals - Kinase Inhibitors

Rho-associated kinase (ROCK) is a serine-threonine kinase known to play an important role in Rho-mediated cytoskeleton remodeling and contractile force generation. Down-regulation of ROCK signaling has been shown to enable the cell-adhesion interactio...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-(phenylmethyl)-2-(4-pyrimidinylamino)-4-thiazolecarboxamide

Correlated keywords:

ROCKs Rhos associated Rho-associated kinases cytoskeletons cells adhesion humans embryonic stems survival self renewal inhibitors inhibits inhibitions iPSC reprogramming SB 431542 PD0325091 pluripotency fibroblasts ALK5 ALK-5 ALKs 5 anaplastic lymphoma SB-431542 SB431542 methyl ethyl ketones MEKs PD-0325091 PDs 0325091 stem cells intracellular signaling signals transductions serine threonine permeable molecules

Product Overview:
Rho-associated kinase (ROCK) is a serine-threonine kinase known to play an important role in Rho-mediated cytoskeleton remodeling and contractile force generation. Down-regulation of ROCK signaling has been shown to enable the cell-adhesion interactions necessary for maintaining human embryonic stem cell survival and self-renewal.{23249} Thiazovivin is a selective, cell-permeable small molecule that inhibits ROCK activity at a concentration 2 µM.{23249} It promotes the survival of induced pluripotent stem cells and improves their reprogramming efficiency from human fibroblasts more than 200 fold when used in combination with the ALK5 inhibitor SB 431542 (Item No. 13031) and the MEK inhibitor PD0325091 (Item No. 13034).{23250}

Size	1 mg
Shipping	dry ice
CAS Number	1226056-71-8
Molecular Formula	C₁₅H₁₃N₅OS
SMILES	O=C(NCC1=CC=CC=C1)C2=CSC(NC3=CC=NC=N3)=N2
Molecular Weight	311,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

Technical File

MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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ISO Guide 34:2009

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