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Carmofur

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    Carmofur
  • Carmofur
Cat No: 14243
Biochemicals - Small Molecule Inhibitors
Cayman

Carmofur is an inhibitor of acid ceramidase (IC50 = 79 nM for the rat enzyme) and a derivative of 5-flurouracil (Item No. 14416).{22147} It reduces acid ceramidase activity in a dose- and time-dependent manner and induces intracellular accumulation of...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 5-fluoro-N-hexyl-3,4-dihydro-2H,4-dioxo-1-pyrimidinecarboxamide
Correlated keywords:
  • biochemical cancer inhibitor intracellular signaling mifurol yamaful acid ceramidase inhibit inhibition anti-neoplastic anti neoplastic adjuvant enzyme tumor C-18 16 14 SW-403
Product Overview:
Carmofur is an inhibitor of acid ceramidase (IC50 = 79 nM for the rat enzyme) and a derivative of 5-flurouracil (Item No. 14416).{22147} It reduces acid ceramidase activity in a dose- and time-dependent manner and induces intracellular accumulation of various ceramide species, including C18 ceramide (Item No. 19556), C16 ceramide (Item No. 24426), and C14 ceramide (Item No. 22531) in SW403 colon and LNCaP prostate cancer cells. Carmofur induces apoptosis in SW403 cells without inhibiting DNA synthesis (IC50 = 1,212 mM for human thymidylate synthetase). It also reduces acid ceramidase activity and increases ceramide accumulation in mouse lung and brain when administered at doses of 10 and 30 mg/kg.
Size 250 mg
Shipping dry ice
CAS Number 61422-45-5
Molecular Formula C11H16FN3O3
SMILES O=C1C(F)=CN(C(NCCCCCC)=O)C(N1)=O
Molecular Weight 257,3
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.59
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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Cross selling for this product : Carmofur There are 8 products.

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