Amlexanox

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Amlexanox

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Cat No: 14181

Biochemicals - Kinase Inhibitors

Amlexanox is an anti-inflammatory and anti-allergic compound which is useful in the amelioration of aphthous ulcers (canker sores), commonly used as a 5% topical oral paste.{22218,22215} By way of mechanism of action, amlexanox associates with the cal...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-amino-7-(1-methylethyl)5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid

Correlated keywords:

inhibits inhibitors inflammation infectious diseases allergy asthma allergies ulcers actin cytoskeleton antinflammatory anti-inflammatory anti inflammatory anti-allergic antiallergic allergic canker sores aphthous amelioration AA673 AA-673 CHX3673 CHX-3673 topical oral pastes inhibits inhibitions non-canonical canonical noncanonical TANK I?K-? aphtheal amoxanox aphtheal Aphthasol Solfa

Product Overview:
Amlexanox is an anti-inflammatory and anti-allergic compound which is useful in the amelioration of aphthous ulcers (canker sores), commonly used as a 5% topical oral paste.{22218,22215} By way of mechanism of action, amlexanox associates with the calcium-binding proteins S100A12 and S100A13, inhibits the release of FGF1, and, at 1 mM, induces changes in the actin cytoskeleton.{22216,22217} More recently, amlexanox has been found to inhibit the non-canonical IKK-ε and TANK-binding kinase 1.{22219}

Size	500 mg
Shipping	dry ice
CAS Number	68302-57-8
Molecular Formula	C₁₆H₁₄N₂O₄
SMILES	CC(C)C1=CC=C2C(C(C(C=C(C(O)=O)C(N)=N3)=C3O2)=O)=C1
Molecular Weight	298,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2918.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.