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A-834735 Degradant

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    A-<wbr/>834735 Degradant
  • A-<wbr/>834735 Degradant
Cat No: 14165
Biochemicals - Analytical Standards
Cayman

A-834735 (Item No. 11163) is an indole-derived cannabinoid (CB) with a 3-tetramethylcyclopropylmethanone substituent. It acts as a full agonist at both the central CB1 and peripheral CB2 receptors in rat with Ki values of 4.6 and 0.31 nM, respectively,...

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Territorial Availability: Available through Bertin Technologies only in France
Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.
Special Advice: Please check regulation status before ordering; additionel fees can apply.
Synonyms:
  • 3,3,4-trimethyl-1-[1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl]-4-penten-1-one
Correlated keywords:
  • cannabinoids agonists CB1 CB2 pains neurosciences analgesia GC-MS fragmentations mass spectrometry chromatography gas McLafferty GC/MS GC MS A834734 A-834,734 A 834,734 834734 834 734 CBs fragments ions indoles 3-tetramethylcyclopropylmethanone blood-brain blood brains barriers hyperalgesia 895155-57-4 receptors agonists neurosciences forensics sciences analgesics derived indole-derived substituents central peripheral rats thermals impurity neuropathic pains models impurities analysis rearrangements analytical references standards
Product Overview:
A-834735 (Item No. 11163) is an indole-derived cannabinoid (CB) with a 3-tetramethylcyclopropylmethanone substituent. It acts as a full agonist at both the central CB1 and peripheral CB2 receptors in rat with Ki values of 4.6 and 0.31 nM, respectively, and EC50 values of 12 and 0.21 nM, respectively.{22084} A-834735 readily crosses the blood-brain barrier, dose-dependently reversing thermal hyperalgesia without adverse side effects in a rat neuropathic pain model.{22084} A-834735 degradant is a common impurity observed during GC-MS analysis of samples containing A-834735. The opened ring of the degradant is presumed to be produced during heating of A-834735. This structure gives rise to a prominent fragment ion that is 15 amu greater than the base peak of A-834735. This pattern is consistent with McLafferty rearrangement of the degradant which does not occur with the parent compound.{21911}
Size 1 mg
Shipping dry ice
CAS Number 2244599-90-2
Molecular Formula C22H29NO2
SMILES O=C(C1=CN(CC2CCOCC2)C3=C1C=CC=C3)CC(C)(C)C(C)=C
Molecular Weight 339,5
Formulation A solution in methanol
Purity ≥95%
Custom Code 3822.19
UNSPSC code 12352100

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