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JMJD2A tudor domains (human, recombinant)

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    JMJD2A tudor domains (human, recombinant)
  • JMJD2A tudor domains (human, recombinant)
Cat No: 14134
Proteins - More Proteins
Cayman

Jumonji Domain Containing 2A (JMJD2A) is a lysine-specific demethylase that catalyzes the demethylation of histone H3 at lysine residues 9 and 36 and histone H1.4 at lysine residue 26.{17970,22334,64097} It is composed of the JmjN N-terminal domain, J...

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: 100 µg

This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
  • JMJD-2A H14 Jmj WB
Product Overview:
Jumonji Domain Containing 2A (JMJD2A) is a lysine-specific demethylase that catalyzes the demethylation of histone H3 at lysine residues 9 and 36 and histone H1.4 at lysine residue 26.{17970,22334,64097} It is composed of the JmjN N-terminal domain, JmjC catalytic domain, two plant homeodomains (PHDs), and two tudor domains that recognize the methylated histones.{64097} JMJD2A is ubiquitously expressed and localized to the nucleus.{18036} It is involved in the regulation of gene expression in a context-dependent manner, having roles in both transcriptional silencing and activation of androgen and estrogen receptors (ERs).{64097} Knockdown of JMJD2A inhibits the proliferation of ER-positive and -negative breast cancer cells and induces apoptosis and cell cycle arrest in colon cancer cells. It is overexpressed in various cancers, including prostate, lung, and colorectal, as well as glioblastomas and endometrial carcinomas, and is associated with higher tumor grade and decreased disease-free survival in breast cancer.{64098} Cayman's JMJD2A tudor domains (human, recombinant) can be used for Western blot (WB) applications.
Size 100 µg
Shipping dry ice
Host E. coli
Application(s)

WB

Formulation 50 mM Tris-HCl, pH 8.0, with 150 mM sodium chloride and 20% glycerol
Purity ≥90% estimated by SDS-PAGE
Custom Code 3504.00
UNSPSC code 12352204

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