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Fludarabine

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    Fludarabine
  • Fludarabine
Cat No: 14128
Biochemicals - Small Molecule Inhibitors
Cayman
€33.00
Price is excluding VAT and does not include packaging neither shipping

Because of their antitumor activity via inhibition of DNA synthesis, purine nucleoside derivatives resistant to deamination have been developed for the treatment of various leukemias.{22555,21535} Fludarabine is an adenosine deaminase resistant analog ...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Pharma only in Europe
Synonyms:
  • 9-β-D-arabinofuranosyl-2-fluoro-9H-purin-6-amine
Correlated keywords:
  • nucleotides apoptosis NSCs 312878 antitumors DNA deoxyribonucleic acids synthesis inhibitors nucleosides analogs leukemia anticancers NSC-312878 NSC312878 inhibits inhibitions anti-cancers anti cancers adenosines deaminases reistant 9-β-D-arabinofuranosyladenine 9-b-D-arabinofuranosyladenine 9-.beta.-D-arabinofuranosyladenine 9-beta-D-arabinofuranosyladenine tumors systems LI210 leukemias CD8F mammary adenocarcinomas P388 LX-1 lungs xenograft hematological malignancies NSC-118218 NSC118218 NSC 118218H antiproliferatives cells lines blood Bax Bid XIAP survivin expressions in vivo purines
Product Overview:
Because of their antitumor activity via inhibition of DNA synthesis, purine nucleoside derivatives resistant to deamination have been developed for the treatment of various leukemias.{22555,21535} Fludarabine is an adenosine deaminase resistant analog of 9-β-D-arabinofuranosyladenine (ara-A) that disrupts ribonucleotide reductase and DNA polymerase in blood cells. It exhibits antiproliferative activity (IC50 = 1.54 μM in an RPMI-8226 myeloma cell line) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP, and survivin expression.{22556,22553} Fludarabine is effective in a number of animal tumor systems including LI210 leukemia, CD8F mammary adenocarcinoma, P388 leukemia, and human LX-1 lung tumor xenograft and displays anticancer activity against human hematological malignancies in vivo.{22565,22552,22557}
Size 5 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 21679-14-1
Molecular Formula C10H12FN5O4
SMILES O[C@@H]1[C@@H](CO)O[C@@H](N2C(N=C(F)N=C3N)=C3N=C2)[C@H]1O
Molecular Weight 285,2
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.49
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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