Diapocynin

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Diapocynin

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Cat No: 14052

Biochemicals - Ox Stress Reagents

Diapocynin is the dimeric form of the NADPH oxidase inhibitor apocynin (Item No. 11976) that has anti-inflammatory and antioxidant activities. Diapocynin inhibits NADPH oxidase complex assembly and activation, gp91phox mRNA expression, and production ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1,1'-(6,6'-dihydroxy-5,5'-dimethoxy[1,1'-biphenyl]-3,3'-diyl)bis-ethanone

Correlated keywords:

1149749-29-0 dehydrodiacetovanillone antiinflammatory anti-oxidant PMBC iPLA-2 SOC SAC LRRK-2 TNF-a TNFa IL10 nicotinamide?adenine dinucleotide phosphate gp91-phox proinflammatory MD LRRK2-R1441G leucine-rich repate kinase NOX interleukin

Product Overview:
Diapocynin is the dimeric form of the NADPH oxidase inhibitor apocynin (Item No. 11976) that has anti-inflammatory and antioxidant activities. Diapocynin inhibits NADPH oxidase complex assembly and activation, gp91phox mRNA expression, and production of the pro-inflammatory cytokines TNF-α and IL-10 in peripheral blood mononuclear cells (PMBCs).{38084} It inhibits production of reactive oxygen species (ROS), calcium-independent isoform of phospholipase A2 (iPLA2) function, and reduces Ca2+ influx through store-operated and stretch-activated channels (SOCs and SACs, respectively) in dystrophic myotubes; all functions in the pathogenic cascade leading to muscular dystrophy.{38083} Diapocynin also reverses motor coordination deficits in the LRRK2R1441G mouse model of early Parkinson's disease.{38082}

Size	1 mg
Shipping	dry ice
CAS Number	29799-22-2
Molecular Formula	C₁₈H₁₈O₆
SMILES	OC1=C(C2=C(O)C(OC)=CC(C(C)=O)=C2)C=C(C(C)=O)C=C1OC
Molecular Weight	330,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.29
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.