AMI-1 (sodium salt)

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AMI-1 (sodium salt)

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Cat No: 13965

AMI-1 is a cell permeable inhibitor of PRMTs. It inhibits both yeast Type I arginine methyltransferase Hmt1p and human PRMT1 (IC50 = 3.0 and 8.8 μM, respectively).{21727} AMI-1 also effectively blocks the activity of PRMTs 3, 4, and 6 but not that of ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

7,7'-(carbonylbis(azanediyl))bis(4-oxidonaphthalene-2-sulfonate), sodium salt

Correlated keywords:

epigenetics inhibitors PRMTs histones modification methyltransferases proteins arginines methyltransferases lysines methyltransferases genes expression cells signaling signals transductions AMI1 AMI 1 permeable inhibits inhibitions yeast type 1 Hmt1p PRMT1 PRMT3 PRMT4, PRMT6, peptide-substrate binding HIV-1 HIV 1 HIV1 reverse transcriptase 20324-87-2 SET-7 DOT-1 nonSET Suv39-H2 H1 H-2 PRMT

Product Overview:
AMI-1 is a cell permeable inhibitor of PRMTs. It inhibits both yeast Type I arginine methyltransferase Hmt1p and human PRMT1 (IC50 = 3.0 and 8.8 μM, respectively).{21727} AMI-1 also effectively blocks the activity of PRMTs 3, 4, and 6 but not that of either SET (Sub39H1, Suv39H2, SET7) or non-SET (DOT1) lysine methyltransferases.{21727} The mechanism of inhibition of PRMTs by AMI-1 involves blocking peptide-substrate binding.{16694} AMI-1 also inhibits HIV-1 reverse transcriptase (IC50 = 5.0 μM).{21726}

Size	5 mg
Shipping	dry ice
Molecular Formula	C₂₁H₁₂N₂O₉S₂ • 4Na
SMILES	O=C(NC1=CC(C=C(S(=O)([O-])=O)C=C2[O-])=C2C=C1)NC3=CC4=C(C([O-])=CC(S(=O)([O-])=O)=C4)C=C3.[Na+].[Na+].[Na+].[Na+]
Molecular Weight	592,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.