N-Oxalylglycine

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N-Oxalylglycine

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Cat No: 13944

Biochemicals - Small Molecule Inhibitors

The jumonji domain-containing protein 2 (JMJD2) subfamily of histone demethylases have been shown to catalyze demethylation of the methylated forms of histone 3 lysine 9 (H3K9) and H3K36 in vitro and in cells.{19159} Because histone demethylases are im...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-(carboxycarbonyl)-glycine

Correlated keywords:

N-oxaloglycine jumonji domain-containing protein JMJD2 histones demethylase cancers inhibitors JMJD2A JMJD2C JMJD2E prolyl hydroxylase domain-containing proteins PHD1 PHD2 JMJDs JMJD-2 JMJD-2A JMJD-2C amides analogs ?-ketoglutarate ? ketoglutarate ?ketoglutarate alpha-ketoglutarate alphaketoglutarate alpha a-ketoglutarate aketoglutarate .alpha.-ketoglutarate .alpha.ketoglutarate .alpha. enzymes inhibits inhibitions PHD1 PHD2 PHDs PHD-1 PHD-2

Product Overview:
The jumonji domain-containing protein 2 (JMJD2) subfamily of histone demethylases have been shown to catalyze demethylation of the methylated forms of histone 3 lysine 9 (H3K9) and H3K36 in vitro and in cells.{19159} Because histone demethylases are implicated in certain diseases, including cancer, selective inhibitors are candidate anticancer agents as well as potential tools for elucidating the biological functions of JMJDs.{18098} N-Oxalylglycine, the amide analog of α-ketoglutarate, is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes, including JMJD2A, JMJD2C, and JMJD2E (IC50s = 250, 500, and 24 μM, respectively).{18003,18511,18060,18061} It can also inhibit the prolyl hydroxylase domain-containing proteins PHD1 and PHD2 with IC50 values of 2.1 and 5.6 μM, respectively.{18511,18060, 18061}

Size	5 mg
Shipping	dry ice
CAS Number	5262-39-5
Molecular Formula	C₄H₅NO₅
SMILES	OC(C(NCC(O)=O)=O)=O
Molecular Weight	147,1
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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