JMJD2E Strep-tagged (human, recombinant)

Proteins - Enzymes

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Cat No: 11237

Proteins - Enzymes

Methylation of lysine residues in core histones plays a critical role in regulating gene expression.{18003} Jumonji domain containing 2E (JMJD2E) catalyzes the demethylation of histone H3 at lysince residue 9.{18004} Like other JmjC protein hydroxylas...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

JMJD2D Jumonji domain demethylase epigenetics FDH KDM4D JmjC protein hydroxylase Strep-Tactin Strep Tactin StrepTactin KDM4DL

Product Overview:
Methylation of lysine residues in core histones plays a critical role in regulating gene expression.{18003} Jumonji domain containing 2E (JMJD2E) catalyzes the demethylation of histone H3 at lysince residue 9.{18004} Like other JmjC protein hydroxylase family members, JMJD2E is an α-ketoglutarate-dependent Fe (II) oxygenase.{17970} Purification of Fe-dependent JmjC family members by IMAC can result in displacement of the catalytic iron and decreased activity, therefore this Strep-tagged protein is purified by affinity chromatography using Strep-Tactin coated resin.{20824} Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylase inhibitors may have the capacity to be anticancer agents.{18003}

Size	100 µg
Shipping	dry ice
Formulation	20 mM HEPES, pH 7.4, and 150 mM sodium chloride
Purity	≥75% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

Technical File

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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